Short answer: OPL does not run on PS3, so it can't be used to load PS2 ISO games on a PS3. Whether a PS3 can play PS2 content at all depends entirely on which specific model you have — here's the accurate breakdown.
The Original PS3 Had Real PS2 Backward Compatibility
The earliest "Fat" PS3 models released in 2006-2007 — depending on region and revision — included genuine PS2 backward compatibility, built either from actual PS2 hardware components (Emotion Engine and Graphics Synthesizer chips) on the very first units, or a hybrid hardware/software emulation layer on slightly later Fat revisions. These consoles can play original PS2 discs natively, with no loader or extra software needed at all.
Sony progressively removed this feature to cut manufacturing costs: later Fat revisions had reduced (software-only, less compatible) PS2 support, and every PS3 Slim and Super Slim model has no PS2 compatibility whatsoever.
What About PS2 ISO Files Specifically (Not Original Discs)?
Native PS3 backward compatibility, where it exists, is built around reading the original physical PS2 disc — it isn't a general-purpose PS2 ISO loader the way OPL is for PS2 hardware. Loading PS2 ISO files on a PS3 falls outside official Sony functionality entirely; within the PS3 homebrew scene there are separate tools built for jailbroken ("CFW") consoles that use PS3's own software PS2 emulation layer, but that's a distinct ecosystem from OPL, requires modifying the PS3's firmware, and has its own compatibility limitations — it isn't something this guide walks through.
The Reliable Ways to Play PS2 Games Today
Real PS2 + OPL
The best compatibility and performance for ISO backups, using FreeMCBoot and Open PS2 Loader. See what OPL is and how to set it up.
Original PS3 (BC Models Only)
Plays original PS2 discs natively if you have a launch-era Fat model with hardware backward compatibility — check your exact model number first.
PCSX2 on PC
A actively developed, high-compatibility PS2 emulator for Windows, Mac, and Linux — the standard choice for playing PS2 ISOs on a computer.
Have a real PS2? That's the easiest path.
Get OPL running and load your ISO backups directly.
Download OPL PS2